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Prime of life neurodegeneration is a spectrum of relatively rare diseases that often afflict people during productive, active years and lead to debilitating symptoms and early death. They are generally categorized as frontotemporal disorders and are characterized by progressive personality, behavior, language and motor decline. These diseases create a level of functional impairment that significantly compromises the ability to carry out activities of daily living. There is currently no treatment and no cure, but there is hope. Research into these diseases may be a gateway to understanding and ultimately preventing, treating and curing more common neurodegenerative diseases like Alzheimer's and Parkinson's. CurePSP is the leading organization within this disease spectrum, providing support for patients, families and caregivers; awareness and education to healthcare professionals; and global research funding. Current research into prime of life diseases, especially progressive supranuclear palsy (PSP), is showing great promise for unlocking the secrets of neurodegeneration.

To provide sport and physical activity opportunities for individuals who are blind or visually impaired to promote their lifelong wellness.

The Seeing Eye is a philanthropic organization whose mission is to enhance the independence, dignity and self-confidence of blind people through the use of Seeing Eye dogs.

RSRT was launched in 2008 to drive research toward a cure for Rett Syndrome and related MECP2 disorders. Our mission is urgent: 15,000 girls and women in the United States and 350,000 globally live with the agonizing symptoms of Rett Syndrome.

We exist to train local Community Health Workers with basic health knowledge and skills to improve the health of their own communities. Our vision is the end of preventable diseases in underprivileged areas globally by Educating, Empowering, and Equipping local health leaders, whose impact will change the course of their community.

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels.

The core mission of the IRSF is to fund research for treatments and a cure for Rett syndrome while enhancing the overall quality of life for those living with Rett syndrome by providing information, programs, and services. In 1983, a small dedicated group of parents whose children had Rett syndrome formed the first non-profit to focus exclusively on Rett syndrome – International Rett Syndrome Association (IRSA). In 2007, IRSA and Rett Syndrome Research Foundation (RSRF) consolidated resources to better serve families and maximize research investments toward a cure. The International Rett Syndrome Foundation (IRSF) emerged with a mission to accelerate research and empower families that builds upon these foundations’ pioneering work toward care and cure. We are walking this journey with you. IRSF is comprised of parents and friends of those diagnosed with Rett syndrome. We are dedicated to empowering families with the latest medical information, offering meaningful support and resources, and advocating for all those living with Rett syndrome. Our strategy is simple but powerful: improve care today and create treatments for tomorrow. IRSF is committed to a full-spectrum approach, providing solutions for everyone living with Rett syndrome. We do this by investing in innovative research, working to build a robust treatment pipeline, and removing barriers to ensure clinical trial success.

Established in the year 2000, the Preeclampsia Foundation is a 501(c)(3) non-profit organization whose mission is to reduce maternal and infant illness and death due to preeclampsia and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving health care practices.

To respond to the needs of people in New Jersey who are affected by Alzheimer's disease and other dementias, by providing programs and community partnerships that increase awareness and access to services.

Our mission is to find a effective treatments and ultimately a cure for fragile X syndrome, the most common inherited cause of autism. We directly fund research grants and fellowships at top universities around the world. FRAXA was founded in 1994 by three parents of children with fragile X. Fragile X Syndrome is the most common inherited cause of autism and intellectual disabilities. It affects 1 in 4000 boys and 1 in 6000 girls worldwide, and one in 260 women and 1 in 800 men are carriers. Treatments for fragile X are likely to help people affected by related disorders including autism, Alzheimers, and many other brain disorders.

Brain Support Network (BSN) is a non-profit, charitable organization dedicated to three missions: 1) Providing information and support for anyone living with an atypical parkinsonism disorder (Progressive supranuclear palsy, Dementia with Lewy bodies, Multiple System Atrophy or Corticobasal degeneration) anywhere in the world; 2) Providing a support for care partners of those living with an atypical parkinsonism disorder in the San Francisco Bay Area; 3) Enabling families living anywhere in the US to donate the brain of anyone with any neurological condition (or healthy controls) to confirm the diagnosis and to further neurological research into causes, treatment options and cures.

Their mission is to promote early detection of brain aneurysms by providing knowledge and raising awareness of the signs, symptoms and risk factors. Work with the medical communities to provide support networks for patients and families, as well as to further research that will improve patient outcomes and save lives.