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The Palestine Children's Relief Fund (PCRF) is a non-political, non-profit organization dedicated to healing the wounds of war, occupation and poverty for children in the Middle East, regardless of their nationality, religion, race or gender.

Habitat for Humanity believes that every man, woman and child should have a decent, safe and affordable place to live. We build and repair houses all over the world using volunteer labor and donations. Our partner families purchase these houses through no-profit, no-interest mortgage loans or innovative financing methods. As a nonprofit, ecumenical Christian ministry that builds with people in need regardless of race or religion, we welcome volunteers and supporters from all backgrounds.

The American Cancer Society’s mission is to improve the lives of people with cancer and their families through advocacy, research, and patient support , to ensure everyone has an opportunity to prevent, find, treat, and survive cancer.

The Trevor Project is the world’s largest suicide prevention and crisis intervention organization for LGBTQ+ (lesbian, gay, bisexual, transgender, queer, and questioning) young people. The organization works to save young lives by providing support through free and confidential suicide prevention and crisis intervention programs on platforms where young people spend their time: a 24/7 phone lifeline, chat, and text. The organization also runs TrevorSpace, the world’s largest safe space social networking site for LGBTQ youth, and operates innovative education, research, and advocacy programs.

RSRT was launched in 2008 to drive research toward a cure for Rett Syndrome and related MECP2 disorders. Our mission is urgent: 15,000 girls and women in the United States and 350,000 globally live with the agonizing symptoms of Rett Syndrome.

Founded in 1988 by Paul Newman, The Hole in the Wall Gang Camp is a community dedicated to providing “a different kind of healing” to children and their families coping with cancer, sickle cell anemia, and other serious illnesses. Through summer sessions and family weekends at the Camp in Ashford, Connecticut and year-round outreach to hospitals and clinics across the Northeast, the Camp serves more than 20,000 children and family members annually. All services are provided free of charge.

As the Drug Discovery Engine for ALS, the ALS Therapy Development Institute (ALS TDI) discovers and invents ALS treatments and partners to advance them into clinical trials. It is the first and largest nonprofit biotech focused 100% on ALS research. ALS TDI incorporates all aspects of drug discovery under one roof to find treatments as quickly as possible. Located in Watertown, MA, ALS TDI employs researchers with over 300 years of combined experience and expertise across all areas of drug discovery. ALS TDI is recognized as an international leader in preclinical and translational ALS research, and partners with pharmaceutical companies and biotechs around the world. Awarded the highest nonprofit rating – four stars – on Charity Navigator, ALS TDI spends 87 cents of every dollar raised on finding effective treatments and cures for ALS.

Children's Aid helps children in poverty to succeed and thrive. We do this by providing comprehensive supports to children and their families in targeted high-needs New York City neighborhoods

Victory Junction enriches the lives of children with serious illnesses by providing life-changing camp experiences that are exciting, fun and empowering, at no cost to children or their families.

The mission of Joslin Diabetes Center is to prevent, treat and cure diabetes. Our vision is a world free of diabetes and its complications.

Virginia Mason Medical Centers the Medical Center mission is to improve the health and well-being of the patients it serves through the delivery of high quality, cost-effective care The Medical Center provides integrated health services through a teaching hospital licensed for 336 beds and multi-specialty group practice of more than full-time 465 physicians

To provide "shalva"--which means "peace of mind" inHebrew--to Israel's mentally and physically challenged children and theirfamilies by --helping each child achieve his/her full potential throughcomprehensive, vanguard programs in a beautiful, caring environment, --providingneeded respite and support to their families, enabling them raise their childat home, with their family, and thereby forego institutionalizing the child,--improving both the child's quality of life and that of the entire family,--advocating on behalf of mentally and challenged children and their familiesin Israel and the world, --providing research and training to enable others toduplicate the Shalva model and its programs --training volunteers to beeffective in working with special needs children and to be exemplary,sensitive, caring individuals