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The National Multiple Sclerosis Society's mission is to cure multiple sclerosis while empowering people affected by multiple sclerosis (MS) to live their best lives. The organization pledges to accelerate cures through global leadership, and improve access to personalized, affordable, high-quality MS healthcare. It empowers people affected by MS to solve everyday challenges and strengthens the MS movement through more and deeper connections.

St. Jude Children's Research Hospital seeks to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of their founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay. St. Jude’s strives to be the world leader in advancing the treatment and prevention of catastrophic diseases in children, by providing outstanding patient care; conducting basic, translational and clinical research designed to elucidate biological mechanisms, understand disease pathogenesis, improve diagnosis, enhance treatment outcome, prevent diseases and minimize adverse consequences of treatment; and by educating health care and scientific research professionals. Treatments invented at St. Jude have helped push the overall childhood cancer survival rate from 20% to more than 80% since it opened more than 50 years ago.

The American Kidney Fund fights kidney disease on all fronts as the nation's leading kidney nonprofit. We work on behalf of the 37 million Americans living with kidney disease, and the millions more at risk, with an unmatched scope of programs that support people wherever they are in their fight against kidney disease — from prevention through post-transplant living.

Impact Network is a U.S.-based charitable organization that provides successful technology based education solutions in rural Africa. We believe every child deserves access to a quality education. By empowering local teachers with tablets loaded with activity-based lessons and intensive training on the use of the technology, we make this possible. We developed the eSchool 360 system as a way to sustain high-quality education for less than $5 a month per student. Our solution is currently operating in over 40 schools in rural Zambia, serving over 6,000 students in the primary grades.

NADAP’s mission is to enable individuals to become healthy, productive and self-sufficient.

RSRT was launched in 2008 to drive research toward a cure for Rett Syndrome and related MECP2 disorders. Our mission is urgent: 15,000 girls and women in the United States and 350,000 globally live with the agonizing symptoms of Rett Syndrome.

Founded in 1988 by Paul Newman, The Hole in the Wall Gang Camp is a community dedicated to providing “a different kind of healing” to children and their families coping with cancer, sickle cell anemia, and other serious illnesses. Through summer sessions and family weekends at the Camp in Ashford, Connecticut and year-round outreach to hospitals and clinics across the Northeast, the Camp serves more than 20,000 children and family members annually. All services are provided free of charge.

As the Drug Discovery Engine for ALS, the ALS Therapy Development Institute (ALS TDI) discovers and invents ALS treatments and partners to advance them into clinical trials. It is the first and largest nonprofit biotech focused 100% on ALS research. ALS TDI incorporates all aspects of drug discovery under one roof to find treatments as quickly as possible. Located in Watertown, MA, ALS TDI employs researchers with over 300 years of combined experience and expertise across all areas of drug discovery. ALS TDI is recognized as an international leader in preclinical and translational ALS research, and partners with pharmaceutical companies and biotechs around the world. Awarded the highest nonprofit rating – four stars – on Charity Navigator, ALS TDI spends 87 cents of every dollar raised on finding effective treatments and cures for ALS.

Children's Aid helps children in poverty to succeed and thrive. We do this by providing comprehensive supports to children and their families in targeted high-needs New York City neighborhoods

Victory Junction enriches the lives of children with serious illnesses by providing life-changing camp experiences that are exciting, fun and empowering, at no cost to children or their families.

The mission of Joslin Diabetes Center is to prevent, treat and cure diabetes. Our vision is a world free of diabetes and its complications.

When a child is born with a severe hearing loss, the impact on the parents and the problems facing the child are staggering. John Tracy Clinic is a place where parents of young deaf children can find hope, guidance and encouragement. Its purpose is to train and support parents in helping their young deaf children develop the communication skills necessary to reach their full potential. The Clinic was founded by Louise Tracy, wife of actor Spencer Tracy, whose son, John, was born deaf.