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The core mission of the IRSF is to fund research for treatments and a cure for Rett syndrome while enhancing the overall quality of life for those living with Rett syndrome by providing information, programs, and services. In 1983, a small dedicated group of parents whose children had Rett syndrome formed the first non-profit to focus exclusively on Rett syndrome – International Rett Syndrome Association (IRSA). In 2007, IRSA and Rett Syndrome Research Foundation (RSRF) consolidated resources to better serve families and maximize research investments toward a cure. The International Rett Syndrome Foundation (IRSF) emerged with a mission to accelerate research and empower families that builds upon these foundations’ pioneering work toward care and cure. We are walking this journey with you. IRSF is comprised of parents and friends of those diagnosed with Rett syndrome. We are dedicated to empowering families with the latest medical information, offering meaningful support and resources, and advocating for all those living with Rett syndrome. Our strategy is simple but powerful: improve care today and create treatments for tomorrow. IRSF is committed to a full-spectrum approach, providing solutions for everyone living with Rett syndrome. We do this by investing in innovative research, working to build a robust treatment pipeline, and removing barriers to ensure clinical trial success.

Leader Dogs for the Blind breeds and trains dogs (and future owners) to assist the blind. Our mission is empowering people who are blind or visually impaired with lifelong skills for safe and independent daily travel. In support of this mission, our actions are guided, supported and measured by our values: Do what is right Respect and compassion Passion for the work Superior experience Teamwork Innovation Safety

Vitamin Angels reduces child mortality worldwide by connecting essential micronutrients with infants and children under five. Essential nutrients, especially vitamin A, help young immune systems fight infectious diseases, helping children attain good health and the opportunity to lead meaningful and productive lives.

Founded in 1919, Braille Institute's mission is to eliminate barriers to a fulfilling life caused by blindness and servere sight loss.

Helen Keller International is a global health organization dedicated to eliminating preventable vision loss, malnutrition, and diseases of poverty.Co-founded by Helen Keller—and guided by her fierce optimism and belief in human potential—the organization delivers life changing health solutions to vulnerable families in places where the need is great but access to care is limited.In the U.S., Africa, and Asia, Helen Keller’s proven, science-based programs empower people to create opportunities in their own lives and build lasting change.

The mission of Southeastern Guide Dogs is to create and nurture a partnership between a visually impaired individual and a guide dog, facilitating life's journey with mobility, independence and dignity.

The Huntington's Disease Society of America is the premier nonprofit organization dedicated to improving the lives of everyone affected by Huntington’s disease. From community services and education to advocacy and research, HDSA is the world’s leader in providing help for today and hope for tomorrow for people with Huntington’s disease and their families. HDSA's network of chapters, affiliates, HDSA Centers of Excellence, social workers and support groups provides a seamless connection for help, education and outreach to HD families and health care professionals across the United States.

The mission of the ChadTough Defeat DIPG Foundation is to inspire and fund game-changing research to discover effective treatments for pediatric brain cancer, with an emphasis on diffuse intrinsic pontine glioma (DIPG).

Learning Ally transforms the lives of new and struggling learners through literacy. By understanding how each student learns, Learning Ally will provide solutions to support and empower educators and students to solve the literacy problem.

Since 1946, the Guide Dog Foundation for the Blind has trained and placed guide and service dogs to provide independence, enhanced mobility, and companionship to people who are blind, have low vision, or who have other special needs. The Guide Dog Foundation serves clients from across the United States and Canada. People come to us for our trademark small classes and personalized instruction, and we have successfully worked with individuals who are deaf-blind and those with disabilities other than blindness or hearing impairment. In addition to our guide and service dog programs, the Foundation offers extensive education and outreach programs to broaden the public's understanding of vision and visual impairment, and access and disability rights.

The Carroll Center for the Blind's mission is to serve the needs of individuals who are blind and visually impaired by providing rehabilitation, skills training, and educational opportunities to achieve independence, self-sufficiency and self-fulfillment, and by educating the public regarding the potential of persons who are blind and visually impaired.

MAKING A DIFFERENCE: IMPROVING QUALITY OF LIFE THROUGH EXCELLENCE IN SERVICE.